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Functional roles of glutamic acid E143 and E705 residues in the N-terminus and transmembrane domain 7 of Anoctamin 1 in calcium and noxious heat sensing

Anoctamin 1 (ANO1) is an anion channel that is activated by changes in cytosolic Ca(2+) concentration and noxious heat. Although the critical roles of ANO1 have been elucidated in various cell types, the control of its gating mechanisms by Ca(2+) and heat remain more elusive. To investigate critical...

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Detalles Bibliográficos
Autores principales: Choi, Jonghyun, Jang, Yongwoo, Kim, Haedong, Wee, Jungwon, Cho, Sinyoung, Son, Woo Sung, Kim, Sung Min, Yang, Young Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988578/
https://www.ncbi.nlm.nih.gov/pubmed/29335069
http://dx.doi.org/10.5483/BMBRep.2018.51.5.199