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Functional roles of glutamic acid E143 and E705 residues in the N-terminus and transmembrane domain 7 of Anoctamin 1 in calcium and noxious heat sensing
Anoctamin 1 (ANO1) is an anion channel that is activated by changes in cytosolic Ca(2+) concentration and noxious heat. Although the critical roles of ANO1 have been elucidated in various cell types, the control of its gating mechanisms by Ca(2+) and heat remain more elusive. To investigate critical...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988578/ https://www.ncbi.nlm.nih.gov/pubmed/29335069 http://dx.doi.org/10.5483/BMBRep.2018.51.5.199 |