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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
Hematopoietic stem cells (HSCs) sustain hematopoiesis throughout life. HSCs exit dormancy to restore hemostasis in response to stressful events, such as acute blood loss, and must return to a quiescent state to prevent their exhaustion and resulting bone marrow failure. HSC activation is driven in p...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988582/ https://www.ncbi.nlm.nih.gov/pubmed/29804890 http://dx.doi.org/10.1016/j.stem.2018.05.003 |