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The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites
BACKGROUND: Following cleavage by caspase 8, the C-terminus of Bid translocates from the cytosol to the mitochondria that is dependent upon structures formed by the mitochondrial-specific lipid cardiolipin. Once associated with mitochondria, truncated Bid (tBid) causes the potent release of cytochro...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59886/ https://www.ncbi.nlm.nih.gov/pubmed/11716782 http://dx.doi.org/10.1186/1471-2121-2-22 |