MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven inflammatory diseases. However, the effect of MCC950 on colonic inflammation has not yet been reported. In the present study we i...

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Detalles Bibliográficos
Autores principales: Perera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale, Eri, Rajaraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988655/
https://www.ncbi.nlm.nih.gov/pubmed/29872077
http://dx.doi.org/10.1038/s41598-018-26775-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988655/
https://www.ncbi.nlm.nih.gov/pubmed/29872077
http://dx.doi.org/10.1038/s41598-018-26775-w

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