Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers

BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Cortes, Jorge, Tamura, Kenji, DeAngelo, Daniel J., de Bono, Johann, Lorente, David, Minden, Mark, Uy, Geoffrey L., Kantarjian, Hagop, Chen, Lisa S., Gandhi, Varsha, Godin, Robert, Keating, Karen, McEachern, Kristen, Vishwanathan, Karthick, Pease, Janet Elizabeth, Dean, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988656/
https://www.ncbi.nlm.nih.gov/pubmed/29765150
http://dx.doi.org/10.1038/s41416-018-0082-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988656/
https://www.ncbi.nlm.nih.gov/pubmed/29765150
http://dx.doi.org/10.1038/s41416-018-0082-1

Ejemplares similares