Cargando…

Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers

BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortes, Jorge, Tamura, Kenji, DeAngelo, Daniel J., de Bono, Johann, Lorente, David, Minden, Mark, Uy, Geoffrey L., Kantarjian, Hagop, Chen, Lisa S., Gandhi, Varsha, Godin, Robert, Keating, Karen, McEachern, Kristen, Vishwanathan, Karthick, Pease, Janet Elizabeth, Dean, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988656/ https://www.ncbi.nlm.nih.gov/pubmed/29765150 http://dx.doi.org/10.1038/s41416-018-0082-1

Ejemplares similares

Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study
por: Chen, Qingqing, et al.
Publicado: (2019)

PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells
por: Cervantes-Gomez, Fabiola, et al.
Publicado: (2019)

Proviral Integration Site for Moloney Murine Leukemia Virus (PIM) Kinases Promote Human T Helper 1 Cell Differentiation
por: Tahvanainen, Johanna, et al.
Publicado: (2013)

Proviral Integration of Moloney Virus-2 (PIM-2) Expression Level as a Prognostic Marker in Patients with Acute Myeloid Leukemia
por: Hamed, Gehad, et al.
Publicado: (2022)

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression
por: Harada, Masako, et al.
Publicado: (2015)

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas
por: Kreuz, S., et al.
Publicado: (2015)

AZD1208, a pan‐Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3‐L1 adipocytes
por: Park, Yu‐Kyoung, et al.
Publicado: (2018)

Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
por: Lee, Miso, et al.
Publicado: (2019)

PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
por: Muñoz-Galván, Sandra, et al.
Publicado: (2020)

COLLABORATION AGREEMENT No. K 1208 & K 1397
por: The European Organisation for Nuclear Research, CERN, et al.
Publicado: (2005)

1208. Omadacycline In Vitro Activity Against Bacillus Anthracis
por: Serio, Alisa W, et al.
Publicado: (2021)

Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer
por: Luszczak, Sabina, et al.
Publicado: (2020)

Studies on mouse Moloney virus induced tumours: I. The detection of p30 as a cytotoxic target on murine Moloney leukaemic spleen cells, and on an in vitro Moloney sarcoma line by antibody mediated cytotoxicity.
por: Epstein, L. B., et al.
Publicado: (1975)

Author Correction: Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer
por: Luszczak, Sabina, et al.
Publicado: (2020)

Economics : a contemporary introduction /
por: McEachern, William A.
Publicado: (1994)

Economía : una introducción contemporánea
por: McEachern, William A.
Publicado: (1998)

Microeconomía : una introducción contemporánea /
por: McEachern, William A.
Publicado: (2003)

Macroeconomía : una introducción contemporánea
por: McEachern, William A.
Publicado: (1998)

Microeconomía : una introducción contemporánea /
por: McEachern, William A.
Publicado: (1998)

Economía : una introducción contemporánea
por: McEachern, William A.
Publicado: (2003)

Macroeconomía : una introducción contemporánea
por: McEachern, William A.
Publicado: (2003)

Transgenic Epigenetics: Using Transgenic Organisms to Examine Epigenetic Phenomena
por: McEachern, Lori A.
Publicado: (2012)

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells
por: Mazzacurati, Lucia, et al.
Publicado: (2015)

EXPERIMENTAL HYPERTHYROIDISM AND ITS EFFECT UPON THE MYOCARDIUM IN GUINEA PIGS AND RABBITS
por: Rake, Geoffrey, et al.
Publicado: (1931)

Enhanced Growth of Syngeneic Moloney Sarcoma with Decreased Immunity in the Regressors
por: Mayer, A. M. S., et al.
Publicado: (1977)

Run 1208, 11.8.1981, Reversible vertical beam enlargement II
por: Koutchouk, Jean-Pierre
Publicado: (1981)

Studies on mouse Moloney virus induced tumours: II. Detection of p30 in the serum of mice with Moloney leukaemia by in vitro blocking of complement dependent antibody mediated cytotoxicity.
por: Epstein, L. B., et al.
Publicado: (1975)

Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling
por: Xu, Jianing, et al.
Publicado: (2012)

In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus.
por: Nanni, P., et al.
Publicado: (1991)

Lentiviral and Moloney Retroviral Expression of Green Fluorescent Protein in Somatotrophs In Vivo
por: Okada, Masayoshi, et al.
Publicado: (2013)

Characterization of the Relationship of Inotuzumab Ozogamicin Exposure With Efficacy and Safety End Points in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia
por: Chen, Joseph, et al.
Publicado: (2020)

Clinical safety profile of ticagrelor compared to clopidogrel in 1208 patients: Real world evidence
por: Kumar, Viveka, et al.
Publicado: (2018)

MiR-1208 Increases the Sensitivity to Cisplatin by Targeting TBCK in Renal Cancer Cells
por: Kim, Eun-Ae, et al.
Publicado: (2019)

Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269
por: Zenkov, Roman G., et al.
Publicado: (2021)

1208. Polymorphic Locus SerMT1 for Sequence-based Typing of Serratia marcescens
por: Edlind, Tom
Publicado: (2022)

Targeting of Moloney murine leukemia virus gag precursor to the site of virus budding
Publicado: (1996)

Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production
por: Wang, Margaret Q, et al.
Publicado: (2004)

Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus
por: Tang, Xuhua, et al.
Publicado: (2016)

Compounds that enhance the tailing activity of Moloney murine leukemia virus reverse transcriptase
por: Ohtsubo, Yoshiyuki, et al.
Publicado: (2017)

Moloney leukemia virus-induced cell surface antigen mimicry by monoclonal antibodies
por: Baskin, Julie G., et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_l41f55jd40mbkkl0igs25jh6c5