Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3

Deletion of the Casp8 gene in epithelial tissues of mice results in severe inflammatory pathologies. Its ubiquitous deletion, or its specific deletion in endothelial cells, results in intrauterine death associated with capillary damage. These pathologies are all preventable by co-deletion of Casp8 a...

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Detalles Bibliográficos
Autores principales: Kang, Tae-Bong, Jeong, Ju-Seong, Yang, Seung-Hoon, Kovalenko, Andrew, Wallach, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988659/
https://www.ncbi.nlm.nih.gov/pubmed/29666472
http://dx.doi.org/10.1038/s41418-018-0104-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988659/
https://www.ncbi.nlm.nih.gov/pubmed/29666472
http://dx.doi.org/10.1038/s41418-018-0104-9

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