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Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues, including the intestine. Consistent with stem cell potential, single isolated LGR5(+) cells from the gut generate self-org...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988707/ https://www.ncbi.nlm.nih.gov/pubmed/29844449 http://dx.doi.org/10.1038/s41416-018-0118-6 |