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Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues, including the intestine. Consistent with stem cell potential, single isolated LGR5(+) cells from the gut generate self-org...

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Detalles Bibliográficos
Autores principales:	Morgan, RG, Mortensson, E, Williams, AC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988707/ https://www.ncbi.nlm.nih.gov/pubmed/29844449 http://dx.doi.org/10.1038/s41416-018-0118-6

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