Dengue envelope-based ‘four-in-one’ virus-like particles produced using Pichia pastoris induce enhancement-lacking, domain III-directed tetravalent neutralising antibodies in mice

Dengue is a significant public health problem worldwide, caused by four antigenically distinct mosquito-borne dengue virus (DENV) serotypes. Antibodies to any given DENV serotype which can afford protection against that serotype tend to enhance infection by other DENV serotypes, by a phenomenon term...

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Detalles Bibliográficos
Autores principales: Rajpoot, Ravi Kant, Shukla, Rahul, Arora, Upasana, Swaminathan, Sathyamangalam, Khanna, Navin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988708/
https://www.ncbi.nlm.nih.gov/pubmed/29872153
http://dx.doi.org/10.1038/s41598-018-26904-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988708/
https://www.ncbi.nlm.nih.gov/pubmed/29872153
http://dx.doi.org/10.1038/s41598-018-26904-5

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