Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

BACKGROUND: Cancer research, in general, is focused on targeting tumour cells to limit tumour growth. These studies, however, do not account for the specific effects of chemotherapy on tumour endothelium, in turn, affecting metastasis. METHODS: We determined how endothelial deletion of Akt1 promotes...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Fei, Alwhaibi, Abdulrahman, Artham, Sandeep, Verma, Arti, Somanath, Payaningal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988746/
https://www.ncbi.nlm.nih.gov/pubmed/29755115
http://dx.doi.org/10.1038/s41416-018-0110-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988746/
https://www.ncbi.nlm.nih.gov/pubmed/29755115
http://dx.doi.org/10.1038/s41416-018-0110-1

Ejemplares similares