Cargando…
First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target
The microsporidia are a large group of intracellular parasites with a broad range of hosts, including humans. Encephalitozoon intestinalis is the second microsporidia species most frequently associated with gastrointestinal disease in humans, especially immunocompromised or immunosuppressed individu...
Autores principales: | García-Torres, Itzhel, De la Mora-De la Mora, Ignacio, Hernández-Alcántara, Gloria, Molina-Ortiz, Dora, Caballero-Salazar, Silvia, Olivos-García, Alfonso, Nava, Gabriela, López-Velázquez, Gabriel, Enríquez-Flores, Sergio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988755/ https://www.ncbi.nlm.nih.gov/pubmed/29872223 http://dx.doi.org/10.1038/s41598-018-26845-z |
Ejemplares similares
-
Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target
por: Enríquez-Flores, Sergio, et al.
Publicado: (2020) -
Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications
por: Enríquez-Flores, Sergio, et al.
Publicado: (2023) -
Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase
por: García-Torres, Itzhel, et al.
Publicado: (2023) -
Structural and Functional Perturbation of Giardia lamblia Triosephosphate Isomerase by Modification of a Non-Catalytic, Non-Conserved Region
por: Hernández-Alcántara, Gloria, et al.
Publicado: (2013) -
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
por: Enríquez-Flores, Sergio, et al.
Publicado: (2022)