Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline

The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's...

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Autores principales: Sampedro, Frederic, Marín-Lahoz, Juan, Martínez-Horta, Saul, Pagonabarraga, Javier, Kulisevsky, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989044/
https://www.ncbi.nlm.nih.gov/pubmed/29899731
http://dx.doi.org/10.3389/fneur.2018.00394
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author Sampedro, Frederic
Marín-Lahoz, Juan
Martínez-Horta, Saul
Pagonabarraga, Javier
Kulisevsky, Jaime
author_facet Sampedro, Frederic
Marín-Lahoz, Juan
Martínez-Horta, Saul
Pagonabarraga, Javier
Kulisevsky, Jaime
author_sort Sampedro, Frederic
collection PubMed
description The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators. Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline.
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spelling pubmed-59890442018-06-13 Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline Sampedro, Frederic Marín-Lahoz, Juan Martínez-Horta, Saul Pagonabarraga, Javier Kulisevsky, Jaime Front Neurol Neurology The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators. Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline. Frontiers Media S.A. 2018-05-30 /pmc/articles/PMC5989044/ /pubmed/29899731 http://dx.doi.org/10.3389/fneur.2018.00394 Text en Copyright © 2018 Sampedro, Marín-Lahoz, Martínez-Horta, Pagonabarraga and Kulisevsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sampedro, Frederic
Marín-Lahoz, Juan
Martínez-Horta, Saul
Pagonabarraga, Javier
Kulisevsky, Jaime
Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title_full Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title_fullStr Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title_full_unstemmed Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title_short Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline
title_sort early gray matter volume loss in mapt h1h1 de novo pd patients: a possible association with cognitive decline
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989044/
https://www.ncbi.nlm.nih.gov/pubmed/29899731
http://dx.doi.org/10.3389/fneur.2018.00394
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