Prophylactic efficacy of orally administered Bacillus poly-γ-glutamic acid, a non-LPS TLR4 ligand, against norovirus infection in mice

Poly-gamma-glutamic acid (γ-PGA), an extracellular biopolymer produced by Bacillus sp., is a non-canonical toll-like receptor 4 (TLR4) agonist. Here we show its antiviral efficacy against noroviruses. γ-PGA with a molecular mass of 2,000-kDa limited murine norovirus (MNV) replication in the macropha...

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Detalles Bibliográficos
Autores principales: Lee, Wooseong, Kim, Minwoo, Lee, Seung-Hoon, Jung, Hae-Gwang, Oh, Jong-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989232/
https://www.ncbi.nlm.nih.gov/pubmed/29875467
http://dx.doi.org/10.1038/s41598-018-26935-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989232/
https://www.ncbi.nlm.nih.gov/pubmed/29875467
http://dx.doi.org/10.1038/s41598-018-26935-y

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