Discovering mutated driver genes through a robust and sparse co-regularized matrix factorization framework with prior information from mRNA expression patterns and interaction network

BACKGROUND: Discovery of mutated driver genes is one of the primary objective for studying tumorigenesis. To discover some relatively low frequently mutated driver genes from somatic mutation data, many existing methods incorporate interaction network as prior information. However, the prior informa...

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Detalles Bibliográficos
Autores principales: Xi, Jianing, Wang, Minghui, Li, Ao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989443/
https://www.ncbi.nlm.nih.gov/pubmed/29871594
http://dx.doi.org/10.1186/s12859-018-2218-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989443/
https://www.ncbi.nlm.nih.gov/pubmed/29871594
http://dx.doi.org/10.1186/s12859-018-2218-y

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