Plakoglobin restores tumor suppressor activity of p53(R175H) mutant by sequestering the oncogenic potential of β‐catenin

Tumor suppressor/transcription factor p53 is mutated in over 50% of all cancers. Some mutant p53 proteins have not only lost tumor suppressor activities but they also gain oncogenic functions (GOF). One of the most frequently expressed GOF p53 mutants is Arg175His (p53(R175H)) with well‐documented r...

Descripción completa

Detalles Bibliográficos
Autores principales: Alaee, Mahsa, Nool, Kristina, Pasdar, Manijeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989865/
https://www.ncbi.nlm.nih.gov/pubmed/29660231
http://dx.doi.org/10.1111/cas.13612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989865/
https://www.ncbi.nlm.nih.gov/pubmed/29660231
http://dx.doi.org/10.1111/cas.13612

Ejemplares similares