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Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan
Diapause in insects is akin to dauer in Caenorhabditis elegans and hibernation in vertebrates. Diapause causes a profound extension of lifespan by low metabolic activity. However, the detailed regulatory mechanisms for low metabolic activity remain unknown. Here, we showed that low pyruvate levels a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990394/ https://www.ncbi.nlm.nih.gov/pubmed/29769432 http://dx.doi.org/10.18632/aging.101447 |