Structural basis of DUX4/IGH-driven transactivation

Oncogenic fusions are major drivers in leukemogenesis and may serve as potent targets for treatment. DUX4/IGHs have been shown to trigger the abnormal expression of ERG(alt) through binding to DUX4-Responsive-Element (DRE), which leads to B-cell differentiation arrest and a full-fledged B-ALL. Here,...

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Detalles Bibliográficos
Autores principales: Dong, Xue, Zhang, Weina, Wu, Haiyan, Huang, Jinyan, Zhang, Ming, Wang, Pengran, Zhang, Hao, Chen, Zhu, Chen, Sai-Juan, Meng, Guoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990521/
https://www.ncbi.nlm.nih.gov/pubmed/29572508
http://dx.doi.org/10.1038/s41375-018-0093-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990521/
https://www.ncbi.nlm.nih.gov/pubmed/29572508
http://dx.doi.org/10.1038/s41375-018-0093-1

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