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Oxidation-specific epitopes restrain bone formation

Atherosclerosis and osteoporosis are epidemiologically linked and oxidation specific epitopes (OSEs), such as phosphocholine (PC) of oxidized phospholipids (PC-OxPL) and malondialdehyde (MDA), are pathogenic in both. The proatherogenic effects of OSEs are opposed by innate immune antibodies. Here we...

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Detalles Bibliográficos
Autores principales: Ambrogini, Elena, Que, Xuchu, Wang, Shuling, Yamaguchi, Fumihiro, Weinstein, Robert S., Tsimikas, Sotirios, Manolagas, Stavros C., Witztum, Joseph L., Jilka, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990540/
https://www.ncbi.nlm.nih.gov/pubmed/29875355
http://dx.doi.org/10.1038/s41467-018-04047-5