Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43

ALS patients exhibit dyslipidemia, hypermetabolism and weight loss; in addition, cellular energetics deficits have been detected prior to denervation. Although evidence that metabolism is altered in ALS is compelling, the mechanisms underlying metabolic dysregulation and the contribution of altered...

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Detalles Bibliográficos
Autores principales: Manzo, Ernesto, O'Conner, Abigail G., Barrows, Jordan M., Shreiner, Dakotah D., Birchak, Gabriel J., Zarnescu, Daniela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990617/
https://www.ncbi.nlm.nih.gov/pubmed/29904341
http://dx.doi.org/10.3389/fnmol.2018.00182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990617/
https://www.ncbi.nlm.nih.gov/pubmed/29904341
http://dx.doi.org/10.3389/fnmol.2018.00182

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