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Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans

Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu. Our understanding of the structure-function relationship of connexin channels relies on X-ray crystallographic data for human c...

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Detalles Bibliográficos
Autores principales: Zonta, Francesco, Buratto, Damiano, Crispino, Giulia, Carrer, Andrea, Bruno, Francesca, Yang, Guang, Mammano, Fabio, Pantano, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990870/
https://www.ncbi.nlm.nih.gov/pubmed/29904340
http://dx.doi.org/10.3389/fnmol.2018.00170