Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

Transcriptional modulation of the process of autophagy involves the transcription factor HLH-30/TFEB. In order to systematically determine the regulatory network of HLH-30/TFEB, we performed a genome-wide RNAi screen in C. elegans and found that silencing the nuclear export protein XPO-1/XPO1 enhanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Silvestrini, Melissa J., Johnson, Joseph R., Kumar, Anita V., Thakurta, Tara G., Blais, Karine, Neill, Zachary A., Marion, Sarah W., St Amand, Victoria, Reenan, Robert A., Lapierre, Louis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991088/
https://www.ncbi.nlm.nih.gov/pubmed/29768192
http://dx.doi.org/10.1016/j.celrep.2018.04.063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991088/
https://www.ncbi.nlm.nih.gov/pubmed/29768192
http://dx.doi.org/10.1016/j.celrep.2018.04.063

Ejemplares similares