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Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan
Transcriptional modulation of the process of autophagy involves the transcription factor HLH-30/TFEB. In order to systematically determine the regulatory network of HLH-30/TFEB, we performed a genome-wide RNAi screen in C. elegans and found that silencing the nuclear export protein XPO-1/XPO1 enhanc...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991088/ https://www.ncbi.nlm.nih.gov/pubmed/29768192 http://dx.doi.org/10.1016/j.celrep.2018.04.063 |