Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model

BACKGROUND: The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. Here, we sought to compare originator and non-orig...

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Detalles Bibliográficos
Autores principales: Luna, Ernesto, Agrawal, Pankaj, Mehta, Riyaz, Boone, Maria E., Vernhes, Charlotte, Denys, Colombe, Small, Robert, Mukherjee, Bhaswati, Tennagels, Norbert, Maerten, Stefan, Drake, Donald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991351/
https://www.ncbi.nlm.nih.gov/pubmed/29874257
http://dx.doi.org/10.1371/journal.pone.0197478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991351/
https://www.ncbi.nlm.nih.gov/pubmed/29874257
http://dx.doi.org/10.1371/journal.pone.0197478

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