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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model
BACKGROUND: The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. Here, we sought to compare originator and non-orig...
Autores principales: | Luna, Ernesto, Agrawal, Pankaj, Mehta, Riyaz, Boone, Maria E., Vernhes, Charlotte, Denys, Colombe, Small, Robert, Mukherjee, Bhaswati, Tennagels, Norbert, Maerten, Stefan, Drake, Donald R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991351/ https://www.ncbi.nlm.nih.gov/pubmed/29874257 http://dx.doi.org/10.1371/journal.pone.0197478 |
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