Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation

A critical issue in transgene delivery studies is immune reactivity to the transgene- encoded protein and its impact on sustained gene expression. Here, we test the hypothesis that immunomodulation by rapamycin can decrease immune reactivity after intrathecal AAV9 delivery of a transgene (GFP) in no...

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Detalles Bibliográficos
Autores principales: Ramsingh, Arlene I., Gray, Steven J., Reilly, Andrew, Koday, Michael, Bratt, Debbie, Koday, Merika Treants, Murnane, Robert, Smedley, Jeremy, Hu, Yuhui, Messer, Anne, Fuller, Deborah Heydenburg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991358/
https://www.ncbi.nlm.nih.gov/pubmed/29874260
http://dx.doi.org/10.1371/journal.pone.0198154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991358/
https://www.ncbi.nlm.nih.gov/pubmed/29874260
http://dx.doi.org/10.1371/journal.pone.0198154

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