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Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection
Pooled CRISPR screens based on lentiviral systems have been widely applied to identify the effect of gene knockout on cellular phenotype. Although many screens were successful, they also have the limitation that genes conferring mild phenotypes or those essential for growth can be overlooked, as eve...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991512/ https://www.ncbi.nlm.nih.gov/pubmed/29712754 http://dx.doi.org/10.1101/gr.230250.117 |