A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells

In mouse embryonic stem cells (mESCs), the expression of provirus and endogenous retroelements is epigenetically repressed. Although many cellular factors involved in retroelement silencing have been identified, the complete molecular mechanism remains elusive. In this study, we performed a genome-w...

Descripción completa

Detalles Bibliográficos
Autores principales: Fukuda, Kei, Okuda, Akihiko, Yusa, Kosuke, Shinkai, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991520/
https://www.ncbi.nlm.nih.gov/pubmed/29728365
http://dx.doi.org/10.1101/gr.227280.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991520/
https://www.ncbi.nlm.nih.gov/pubmed/29728365
http://dx.doi.org/10.1101/gr.227280.117

Ejemplares similares