Histone depletion prevents telomere fusions in pre-senescent cells

Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during pre-senescence by preventing telomere-telomere fusions (T-TFs) and the subsequent genet...

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Detalles Bibliográficos
Autores principales: Barrientos-Moreno, Marta, Murillo-Pineda, Marina, Muñoz-Cabello, Ana M., Prado, Félix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991667/
https://www.ncbi.nlm.nih.gov/pubmed/29879139
http://dx.doi.org/10.1371/journal.pgen.1007407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991667/
https://www.ncbi.nlm.nih.gov/pubmed/29879139
http://dx.doi.org/10.1371/journal.pgen.1007407

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