Cargando…

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor growth have been described, therefore targeting PTK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Luping, Levine, Kymberly, Gajiwala, Ketan S., Cronin, Ciarán N., Nagata, Asako, Johnson, Eric, Kraus, Michelle, Tatlock, John, Kania, Robert, Foley, Timothy, Sun, Shaoxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991704/ https://www.ncbi.nlm.nih.gov/pubmed/29879184 http://dx.doi.org/10.1371/journal.pone.0198374

Ejemplares similares

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer
por: Wozniak, Darren J., et al.
Publicado: (2017)

Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling
por: Shin, Won-Sik, et al.
Publicado: (2023)

PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma
por: Liu, Kang, et al.
Publicado: (2017)

The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib(®))
por: GAUMANN, ANDREAS K.A., et al.
Publicado: (2014)

Anti-PTK7 Monoclonal Antibodies Inhibit Angiogenesis by Suppressing PTK7 Function
por: Oh, Si Won, et al.
Publicado: (2022)

Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages
por: Wong, Dennis, et al.
Publicado: (2018)

Kinetochore microtubules in PTK cells
Publicado: (1992)

Repeated phototherapeutic keratectomy (PTK) followed by PTK with photorefractive keratectomy for anterior granular corneal dystrophy
por: Sridhar, Uma, et al.
Publicado: (2020)

PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells
por: Shin, Won-Sik, et al.
Publicado: (2022)

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
por: Lang, Yaw-Dong, et al.
Publicado: (2019)

Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma
por: Lee, Jasmine Y., et al.
Publicado: (2023)

Interpolar spindle microtubules in PTK cells
Publicado: (1993)

Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes
por: Tupper, J., et al.
Publicado: (2011)

Characterization of Atypical Protein Tyrosine Kinase (PTK) Genes and Their Role in Abiotic Stress Response in Rice
por: Elangovan, Allimuthu, et al.
Publicado: (2020)

Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF
por: Shin, Won-Sik, et al.
Publicado: (2019)

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase
por: Moccia, Marialuisa, et al.
Publicado: (2015)

PTK7 Faces the Wnt in Development and Disease
por: Berger, Hanna, et al.
Publicado: (2017)

Oncogenic drivers and mitochondrial dependency
por: Alvarez-Calderon, Francesca, et al.
Publicado: (2015)

The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis
por: Gerwig, Jan, et al.
Publicado: (2014)

The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis
por: Su, Zhe, et al.
Publicado: (2021)

PTK2 and PTPN11 expression in myelodysplastic syndromes
por: Lazarini, Mariana, et al.
Publicado: (2013)

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients
por: Aubele, M, et al.
Publicado: (2008)

Expression of protein tyrosine kinase 6 (PTK6) in nonsmall cell lung cancer and their clinical and prognostic significance
por: Zhao, Chao, et al.
Publicado: (2013)

Substrate Specificity of the Bacillus subtilis BY-Kinase PtkA Is Controlled by Alternative Activators: TkmA and SalA
por: Derouiche, Abderahmane, et al.
Publicado: (2016)

Oncogenic driver mutations in lung cancer
por: Luo, Susan Y, et al.
Publicado: (2013)

OR16-02 Histone ADP-Ribosylation Site Mutations As Oncogenic Drivers In Breast And Ovarian Cancers
por: Huang, Dan, et al.
Publicado: (2023)

Overexpression of PTK6 predicts poor prognosis in bladder cancer patients
por: Xu, Xue-lian, et al.
Publicado: (2017)

Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro
por: Burmi, Rajpal S., et al.
Publicado: (2022)

Structural polarity of kinetochore microtubules in PtK1 cells
Publicado: (1981)

Ptk7 Marks the First Human Developmental EMT In Vitro
por: Chan, David N., et al.
Publicado: (2012)

Variants identified in PTK7 associated with neural tube defects
por: Lei, Yunping, et al.
Publicado: (2019)

PTK-7 Expression in Gastric Cancer: A Prognostic Determinant
por: Özçelik, Melike, et al.
Publicado: (2020)

The long tail of oncogenic drivers in prostate cancer
por: Armenia, Joshua, et al.
Publicado: (2018)

Oncogenic Viruses as Entropic Drivers of Cancer Evolution
por: Tempera, Italo, et al.
Publicado: (2021)

Editorial: Immunotherapy for NSCLC with oncogenic driver variants
por: Du, Yijia, et al.
Publicado: (2022)

Long-range replica exchange molecular dynamics guided drug repurposing against tyrosine kinase PtkA of Mycobacterium tuberculosis
por: Nagpal, Priya, et al.
Publicado: (2020)

Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance
por: Jiang, Zhipeng, et al.
Publicado: (2022)

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
por: Wang, Di, et al.
Publicado: (2022)

Oncogenic driver genes and tumor microenvironment determine the type of liver cancer
por: Wang, Gang, et al.
Publicado: (2020)

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival
por: Irie, Hanna Y., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_q726cvdud5vifg1su2p4eaekr0