An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients

Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4), a negative regulator of T-cell function, is increased in chronic HIV-1 infection. It was hypothesized that CTLA-4 blockade may enhance immune response to HIV-1 and result in better control of viremia. This open-label, multiple ascending dose s...

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Detalles Bibliográficos
Autores principales: Colston, Elizabeth, Grasela, Dennis, Gardiner, David, Bucy, R. Pat, Vakkalagadda, Blisse, Korman, Alan J., Lowy, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991705/
https://www.ncbi.nlm.nih.gov/pubmed/29879143
http://dx.doi.org/10.1371/journal.pone.0198158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991705/
https://www.ncbi.nlm.nih.gov/pubmed/29879143
http://dx.doi.org/10.1371/journal.pone.0198158

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