Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma

Clear cell sarcoma (CCS) is an aggressive type of soft tissue tumor that is associated with high rates of metastasis. In the present study, we found that CPI-613, which targets tumorous mitochondrial energy metabolism, induced autophagosome formation followed by lysosome fusion in HS-MM CCS cells in...

Descripción completa

Detalles Bibliográficos
Autores principales: Egawa, Yuki, Saigo, Chiemi, Kito, Yusuke, Moriki, Toshiaki, Takeuchi, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991736/
https://www.ncbi.nlm.nih.gov/pubmed/29879220
http://dx.doi.org/10.1371/journal.pone.0198940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991736/
https://www.ncbi.nlm.nih.gov/pubmed/29879220
http://dx.doi.org/10.1371/journal.pone.0198940

Ejemplares similares