Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus

Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are markedly attenuated in mice and fail to counter cellular double-...

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Detalles Bibliográficos
Autores principales: Burgess, Hannah M., Pourchet, Aldo, Hajdu, Cristina H., Chiriboga, Luis, Frey, Alan B., Mohr, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991893/
https://www.ncbi.nlm.nih.gov/pubmed/29888320
http://dx.doi.org/10.1016/j.omto.2018.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991893/
https://www.ncbi.nlm.nih.gov/pubmed/29888320
http://dx.doi.org/10.1016/j.omto.2018.01.001

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