LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiat...

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Detalles Bibliográficos
Autores principales: Chen, Zhenzhen, Gao, Yanfeng, Yao, Lintong, Liu, Yating, Huang, Lan, Yan, Zhongyi, Zhao, Wenshan, Zhu, Pingping, Weng, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992127/
https://www.ncbi.nlm.nih.gov/pubmed/29535420
http://dx.doi.org/10.1038/s41388-018-0203-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992127/
https://www.ncbi.nlm.nih.gov/pubmed/29535420
http://dx.doi.org/10.1038/s41388-018-0203-6

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