Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity

The lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of Cathepsin K protects mice against cardiac dysfunction. Whether this is attributable to a direct effect on cardiomyocytes or is a consequence of th...

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Detalles Bibliográficos
Autores principales: Guo, Rui, Hua, Yinan, Ren, Jun, Bornfeldt, Karin E., Nair, Sreejayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992138/
https://www.ncbi.nlm.nih.gov/pubmed/29880809
http://dx.doi.org/10.1038/s41419-018-0727-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992138/
https://www.ncbi.nlm.nih.gov/pubmed/29880809
http://dx.doi.org/10.1038/s41419-018-0727-2

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