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Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
The lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of Cathepsin K protects mice against cardiac dysfunction. Whether this is attributable to a direct effect on cardiomyocytes or is a consequence of th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992138/ https://www.ncbi.nlm.nih.gov/pubmed/29880809 http://dx.doi.org/10.1038/s41419-018-0727-2 |