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Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

The first RNA recognition motif of the Drosophila SNF protein is an example of an RNA binding protein with multi-specificity. It binds different RNA hairpin loops in spliceosomal U1 or U2 small nuclear RNAs, and only in the latter case requires the auxiliary U2A′ protein. Here we investigate its fun...

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Detalles Bibliográficos
Autores principales: Weber, Gert, DeKoster, Gregory T., Holton, Nicole, Hall, Kathleen B., Wahl, Markus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992148/
https://www.ncbi.nlm.nih.gov/pubmed/29880797
http://dx.doi.org/10.1038/s41467-018-04561-6