Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch

APOL1 risk alleles G1 or G2 are associated with a kidney disease phenotype exclusively in people of recent African ancestry. Here we show that exon 4 encoding a part of the APOL1 signal peptide is constitutively spliced in major APOL1 transcripts expressed in kidney glomerular and tubular cells. We...

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Detalles Bibliográficos
Autores principales: Cheatham, Amber M., Davis, Shamara E., Khatua, Atanu K., Popik, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992166/
https://www.ncbi.nlm.nih.gov/pubmed/29880816
http://dx.doi.org/10.1038/s41598-018-27104-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992166/
https://www.ncbi.nlm.nih.gov/pubmed/29880816
http://dx.doi.org/10.1038/s41598-018-27104-x

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