Cargando…
Novel interaction between Alzheimer’s disease-related protein presenilin 1 and glutamate transporter 1
Neuronal hyperactivity is one of the earliest events observed in Alzheimer’s disease (AD). Moreover, alterations in the expression of glutamate transporters have been reported to exacerbate amyloid pathology and cognitive deficits in transgenic AD mouse models. However, the molecular links between t...
Autores principales: | Zoltowska, Katarzyna Marta, Maesako, Masato, Meier, Joshua, Berezovska, Oksana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992168/ https://www.ncbi.nlm.nih.gov/pubmed/29880815 http://dx.doi.org/10.1038/s41598-018-26888-2 |
Ejemplares similares
-
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
por: Zoltowska, Katarzyna Marta, et al.
Publicado: (2017) -
Presenilin 1 increases association with synaptotagmin 1 during normal aging
por: Keller, Laura J., et al.
Publicado: (2019) -
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
por: Kuzuya, Akira, et al.
Publicado: (2016) -
Synapsin 1 promotes Aβ generation via BACE1 modulation
por: Maesako, Masato, et al.
Publicado: (2019) -
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease
por: Perrin, Florian, et al.
Publicado: (2023)