Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells

Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide synthesis. In this study, we used exon splicing mo...

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Detalles Bibliográficos
Autores principales: Woo, Chern Chiuh, Kaur, Kavita, Chan, Wei Xin, Teo, Xing Qi, Lee, Teck Hock Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992284/
https://www.ncbi.nlm.nih.gov/pubmed/29911072
http://dx.doi.org/10.3389/fonc.2018.00196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992284/
https://www.ncbi.nlm.nih.gov/pubmed/29911072
http://dx.doi.org/10.3389/fonc.2018.00196

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