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Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells
Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide synthesis. In this study, we used exon splicing mo...
Autores principales: | Woo, Chern Chiuh, Kaur, Kavita, Chan, Wei Xin, Teo, Xing Qi, Lee, Teck Hock Philip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992284/ https://www.ncbi.nlm.nih.gov/pubmed/29911072 http://dx.doi.org/10.3389/fonc.2018.00196 |
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