Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation

Parkinson’s disease (PD) is one of the most prevalent forms of synucleinopathies, and it is characterized neuropathologically by the presence of intracellular inclusions composed primarily of the protein α-synuclein (α-syn) in neurons. The previous immunotherapy targeting the α-syn in PD models with...

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Detalles Bibliográficos
Autores principales: Zheng, Yuan, Qu, Jing, Xue, Fenqin, Zheng, Yan, Yang, Bo, Chang, Yongchang, Yang, Hui, Zhang, Jianliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992446/
https://www.ncbi.nlm.nih.gov/pubmed/29858057
http://dx.doi.org/10.1016/j.omtn.2018.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992446/
https://www.ncbi.nlm.nih.gov/pubmed/29858057
http://dx.doi.org/10.1016/j.omtn.2018.02.011

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