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Tbx6 controls left-right asymmetry through regulation of Gdf1

The Tbx6 transcription factor plays multiple roles during gastrulation, somite formation and body axis determination. One of the notable features of the Tbx6 homozygous mutant phenotype is randomization of left/right axis determination. Cilia of the node are morphologically abnormal, leading to the...

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Detalles Bibliográficos
Autores principales: Concepcion, Daniel, Hamada, Hiroshi, Papaioannou, Virginia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992533/
https://www.ncbi.nlm.nih.gov/pubmed/29650695
http://dx.doi.org/10.1242/bio.032565