The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

BACKGROUND: Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with constitutive RhoGEF activity. We investigated whether the subcellular location of...

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Detalles Bibliográficos
Autores principales: van Unen, J., Botman, D., Yin, T., Wu, Y. I., Hink, M. A., Gadella, T. W. J., Postma, M., Goedhart, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992656/
https://www.ncbi.nlm.nih.gov/pubmed/29879899
http://dx.doi.org/10.1186/s12860-018-0155-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992656/
https://www.ncbi.nlm.nih.gov/pubmed/29879899
http://dx.doi.org/10.1186/s12860-018-0155-2

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