Cargando…

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

BACKGROUND: Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. METHODS: We developed and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zeran, Del-Aguila, Jorge L., Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J., Dougherty, Joseph D., Lee, Jin-Moo, Morris, John C., Bateman, Randall J., Karch, Celeste M., Cruchaga, Carlos, Harari, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992755/ https://www.ncbi.nlm.nih.gov/pubmed/29880032 http://dx.doi.org/10.1186/s13073-018-0551-4

Ejemplares similares

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
por: Jiang, Shan, et al.
Publicado: (2018)

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
por: Del-Aguila, Jorge L., et al.
Publicado: (2019)

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
por: Dube, Umber, et al.
Publicado: (2019)

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels
por: Ibanez, Laura, et al.
Publicado: (2017)

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
por: Del-Aguila, Jorge L., et al.
Publicado: (2019)

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease
por: Fernández, Maria Victoria, et al.
Publicado: (2017)

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease
por: Fernández, Maria V., et al.
Publicado: (2018)

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer’s disease brains
por: Novotny, Brenna C., et al.
Publicado: (2023)

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
por: Yang, Chengran, et al.
Publicado: (2021)

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease
por: Ibanez, Laura, et al.
Publicado: (2020)

Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease
por: Li, Fuhai, et al.
Publicado: (2021)

Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans
por: Del-Aguila, Jorge L., et al.
Publicado: (2015)

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
por: Brase, Logan, et al.
Publicado: (2023)

Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease
por: Li, Fuhai, et al.
Publicado: (2022)

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease
por: Ibanez, Laura, et al.
Publicado: (2018)

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling
por: Minaya, Miguel A., et al.
Publicado: (2023)

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
por: Deming, Yuetiva, et al.
Publicado: (2016)

Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease
por: Chen, Hsiang-Han, et al.
Publicado: (2022)

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains
por: Karch, Celeste M., et al.
Publicado: (2012)

Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
por: Maxwell, Taylor J., et al.
Publicado: (2018)

Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss
por: Benitez, Bruno A., et al.
Publicado: (2015)

Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
por: Mahali, Sidhartha, et al.
Publicado: (2022)

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network
por: Karch, Celeste M., et al.
Publicado: (2018)

Discovery and validation of autosomal dominant Alzheimer’s disease mutations
por: Hsu, Simon, et al.
Publicado: (2018)

MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state
por: You, Shih-Feng, et al.
Publicado: (2023)

Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
por: Kauwe, John S. K., et al.
Publicado: (2014)

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
por: Deming, Yuetiva, et al.
Publicado: (2016)

Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population
por: Kirola, Laxmi, et al.
Publicado: (2021)

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction
por: Ezerskiy, Lubov A., et al.
Publicado: (2022)

Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease
por: Kauwe, John S. K., et al.
Publicado: (2011)

Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression
por: Saito, Erin R., et al.
Publicado: (2021)

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes
por: Yang, Chengran, et al.
Publicado: (2022)

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
por: Kober, Daniel L, et al.
Publicado: (2016)

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease
por: Joseph-Mathurin, Nelly, et al.
Publicado: (2018)

Monoamine Innervation of the Cerebral Cortex
por: Krystal, John H.
Publicado: (1985)

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
por: Suárez‐Calvet, Marc, et al.
Publicado: (2018)

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains
por: Esparza, Thomas J., et al.
Publicado: (2016)

The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers
por: Benitez, Bruno A., et al.
Publicado: (2013)

Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy
por: Salegio, Ernesto A., et al.
Publicado: (2014)

Action Initiation in the Human Dorsal Anterior Cingulate Cortex
por: Srinivasan, Lakshminarayan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2silsn9cgoeo3rnugvc3t6krir