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Beyond total treatment effects in randomised controlled trials: Baseline measurement of intermediate outcomes needed to reduce confounding in mediation investigations

BACKGROUND: Random allocation avoids confounding bias when estimating the average treatment effect. For continuous outcomes measured at post-treatment as well as prior to randomisation (baseline), analyses based on (A) post-treatment outcome alone, (B) change scores over the treatment phase or (C) c...

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Detalles Bibliográficos
Autores principales: Landau, Sabine, Emsley, Richard, Dunn, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992850/
https://www.ncbi.nlm.nih.gov/pubmed/29552919
http://dx.doi.org/10.1177/1740774518760300