Cargando…

Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus

BACKGROUND: Regulatory genes play critical roles in natural product biosynthetic pathways. Chromomycins are promising anticancer natural products from actinomycetes. This study is aimed to create an efficient strain for production of these molecules by manipulating the regulatory genes. RESULTS: A p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Lei, Zeng, Jia, Cui, Peiwu, Wang, Wei, Yu, Dayu, Zhan, Jixun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992853/ https://www.ncbi.nlm.nih.gov/pubmed/29977332 http://dx.doi.org/10.1186/s13036-018-0103-x

Ejemplares similares

Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus
por: Cho, Eunji, et al.
Publicado: (2020)

Chromomycin A2 Induces Autophagy in Melanoma Cells
por: Guimarães, Larissa Alves, et al.
Publicado: (2014)

Targeting the Oncogenic TBX2 Transcription Factor With Chromomycins
por: Sahm, Bianca Del B., et al.
Publicado: (2020)

Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli
por: Yuan, Haina, et al.
Publicado: (2019)

Chromomycin A(5) induces bona fide immunogenic cell death in melanoma
por: Florêncio, Katharine Gurgel Dias, et al.
Publicado: (2022)

Chromomycin A(2) potently inhibits glucose-stimulated insulin secretion from pancreatic β cells
por: Kalwat, Michael A., et al.
Publicado: (2018)

Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii
por: Li, Zhong, et al.
Publicado: (2021)

Discovery and engineering of an endophytic Pseudomonas strain from Taxus chinensis for efficient production of zeaxanthin diglucoside
por: Fidan, Ozkan, et al.
Publicado: (2019)

The Crucial Role of Divalent Metal Ions in the DNA-Acting Efficacy and Inhibition of the Transcription of Dimeric Chromomycin A3
por: Hsu, Chun-Wei, et al.
Publicado: (2012)

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases
por: Yu, Dayu, et al.
Publicado: (2017)

Chromomycins A(2) and A(3) from Marine Actinomycetes with TRAIL Resistance-Overcoming and Wnt Signal Inhibitory Activities
por: Toume, Kazufumi, et al.
Publicado: (2014)

The chromomycin CmmA acetyltransferase: a membrane‐bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin
por: García, Beatriz, et al.
Publicado: (2011)

Editorial: Microbial production of medicinally important agents
por: Zeng, Jia, et al.
Publicado: (2023)

Interrogation of Streptomyces avermitilis for efficient production of avermectins
por: Chen, Jinsong, et al.
Publicado: (2016)

Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex
por: Chen, Yu-Wen, et al.
Publicado: (2018)

Chromomycin A3 suppresses cholangiocarcinoma growth by induction of S phase cell cycle arrest and suppression of Sp1-related anti-apoptotic proteins
por: Saranaruk, Paksiree, et al.
Publicado: (2020)

Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA
por: Yushchuk, Oleksandr, et al.
Publicado: (2021)

The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining
por: Xia, Haiyang, et al.
Publicado: (2020)

Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor
por: Bowyer, Jack E., et al.
Publicado: (2017)

Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570
por: Zhao, Houyuan, et al.
Publicado: (2016)

Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus
por: Yin, Shouliang, et al.
Publicado: (2015)

Corrigendum: The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining
por: Xia, Haiyang, et al.
Publicado: (2021)

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
por: Goranovič, Dušan, et al.
Publicado: (2012)

Comparative Genomic and Regulatory Analyses of Natamycin Production of Streptomyces lydicus A02
por: Wu, Huiling, et al.
Publicado: (2017)

Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase
por: Xu, Fuchao, et al.
Publicado: (2019)

Regulatory Control of Rishirilide(s) Biosynthesis in Streptomyces bottropensis
por: Tsypik, Olga, et al.
Publicado: (2021)

Function and Evolution of Two Forms of SecDF Homologs in Streptomyces coelicolor
por: Zhou, Zhan, et al.
Publicado: (2014)

Manipulation and transport of antiprotons for an efficient production of antihydrogen atoms
por: Tajima, Minori, et al.
Publicado: (2017)

Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus
por: Jiang, Yu-Xi, et al.
Publicado: (2023)

Genome-wide inference of regulatory networks in Streptomyces coelicolor
por: Castro-Melchor, Marlene, et al.
Publicado: (2010)

Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis
por: Lin, Chun-Yan, et al.
Publicado: (2020)

Efficient manipulations of circularly polarized terahertz waves with transmissive metasurfaces
por: Jia, Min, et al.
Publicado: (2019)

Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor
por: Yepes, Ana, et al.
Publicado: (2011)

Poly R decolorization and APPL production by Streptomyces violaceoruber and Streptomyces spiroverticillatus
por: Abou-Dobara, M.I., et al.
Publicado: (2015)

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
por: Chen, Yihua, et al.
Publicado: (2010)

The Cellular Mechanisms that Ensure an Efficient Secretion in Streptomyces
por: Gullón, Sonia, et al.
Publicado: (2018)

Enhanced Oxytetracycline Production by Streptomyces rimosus in Submerged Co-Cultures with Streptomyces noursei
por: Boruta, Tomasz, et al.
Publicado: (2021)

Development of a native-locus dual reporter system for the efficient screening of the hyper-production of natural products in Streptomyces
por: Zhou, Jing-Yi, et al.
Publicado: (2023)

Establishment of a highly efficient conjugation protocol for Streptomyces kanamyceticus ATCC12853
por: Zhang, Shuman, et al.
Publicado: (2018)

Efficient production of secretory Streptomyces clavuligerus β-lactamase inhibitory protein (BLIP) in Pichia pastoris
por: Law, Kin-Ho, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5nij34kdf7v30m77edkheds7p4