Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators

In the clinical setting, analgesic tolerance is a primary driver of diminished pain control and opioid dose escalations. Integral to this process are primary afferent sensory neurons, the first-order components of nociceptive sensation. Here, we characterize the factors modulating morphine action an...

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Detalles Bibliográficos
Autores principales: Mischel, Ryan A., Dewey, William L., Akbarali, Hamid I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993194/
https://www.ncbi.nlm.nih.gov/pubmed/29888757
http://dx.doi.org/10.1016/j.isci.2018.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993194/
https://www.ncbi.nlm.nih.gov/pubmed/29888757
http://dx.doi.org/10.1016/j.isci.2018.03.003

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