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Mutation Signatures Including APOBEC in Cancer Cell Lines

BACKGROUND: Multiple endogenous and exogenous sources of DNA damage contribute to the overall mutation burden in cancer, with distinct and overlapping combinations contributing to each cancer type. Many mutation sources result in characteristic mutation signatures, which can be deduced from tumor ge...

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Detalles Bibliográficos
Autores principales: Jarvis, Matthew C, Ebrahimi, Diako, Temiz, Nuri A, Harris, Reuben S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993214/
https://www.ncbi.nlm.nih.gov/pubmed/29888758
http://dx.doi.org/10.1093/jncics/pky002