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Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission
Borrelia burgdorferi sensu lato (Bbsl), the causative agent of Lyme disease, establishes an initial infection in the host’s skin following a tick bite, and then disseminates to distant organs, leading to multisystem manifestations. Tick-to-vertebrate host transmission requires that Bbsl survives dur...
Autores principales: | Hart, Thomas, Nguyen, Ngoc Thien Thu, Nowak, Nancy A., Zhang, Fuming, Linhardt, Robert J., Diuk-Wasser, Maria, Ram, Sanjay, Kraiczy, Peter, Lin, Yi-Pin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993331/ https://www.ncbi.nlm.nih.gov/pubmed/29813137 http://dx.doi.org/10.1371/journal.ppat.1007106 |
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